SAM-e is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones. SAM-e is the methyl donor that catalyzes the production of epinephrine, melatonin, glutathione and the amino acids cysteine and taurine. SAM-e is also known to upregulate the production of critical membrane phospholipids including phosphatidylcholine. SAM-e is also a sulfur donor and, for this reason, is critical for the formation of sulfur-containing proteoglycans in joint connective tissue.

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In recent years, St. John's wort has become the primary botanical for supporting mental well-being. Planetary Herbals Full Spectrum? St. John's Wort Extract combines a standardized hypericin extract with a flavonoid-rich (4:1) concentrate of blosssoming St. John's wort tops. Each tablet contains a minimum of 1.5 mg of pure hypericin.

Regular Price: $16.75
Our Price: $13.4

In recent years, St. John's wort has become the primary botanical for supporting mental well-being. Planetary Herbals Full Spectrum? St. John's Wort Extract combines a standardized hypericin extract with a flavonoid-rich (4:1) concentrate of blosssoming St. John's wort tops. Each tablet contains a minimum of 1.5 mg of pure hypericin.

Regular Price: $31.5
Our Price: $25.2

Planetary Herbals St. John's Wort Emotional Balance? unites a standardized extract of Europe's legendary St. John's wort with the Chinese classic formula Xiao Yao Wan. These herbs have been widely scientifically researched and have a long history of traditional use for supporting a positive and stable emotional state.

Regular Price: $44.98
Our Price: $35.98

Planetary Herbals St. John's Wort Emotional Balance? unites a standardized extract of Europe's legendary St. John's wort with the Chinese classic formula Xiao Yao Wan. These herbs have been widely scientifically researched and have a long history of traditional use for supporting a positive and stable emotional state.

Regular Price: $23.5
Our Price: $18.8

Planetary Herbals St. John's Wort Emotional Balance? unites a standardized extract of Europe's legendary St. John's wort with the Chinese classic formula Xiao Yao Wan. These herbs have been widely scientifically researched and have a long history of traditional use for supporting a positive and stable emotional state.

Regular Price: $12.5
Our Price: $10

A powerful, natural nutrient, S-adenosyl methionine (SAM-e) promotes healthy mood, liver and joint function. Numerous studies going back two decades, including a 2002 study sponsored by the U.S. Department of Health and Human Resources (HHS), show that SAM-e is quite safe and effective for promoting healthy mood and liver function, as well as joint function. SAM-e supplementation benefits aging people, as they are prone to experience joint discomfort and immobilization. NSI? SAM-e is pharmaceutical grade, full potency, and stabilized. SAM-e supplements contain amounts of both the active SS form and the inactive RS form. NSI SAM-e undergoes a natural process of microbiological fermentation, and is then specially processed without solvents. This process ensures an active SS level of 68-80%, the highest concentration available.

SAM-e is believed to raise the levels of specific neurotransmitters, especially that of dopamine, which is important for mood regulation. Higher SAM-e levels in the brain are associated with successful improvement of mood. While not as powerful as antidepressants, a study published in the Journal of Psychiatric Research showed that SAM-e takes effect within one week, quicker than that of drug antidepressants, as well as St. John's Wort. And unlike antidepressants, SAM-e does not lead to such typical side effects as weight gain, headaches, and sexual dysfunction.

Studies published in the American Journal of Medicine show that SAM-e may benefit joint health. Studies have shown that SAM-e may be effective for improving joint function and reducing pain. SAM-e boosts natural antioxidant levels, and may provide benefits for health concerns including liver health, muscle health and homocysteine levels. In the liver, SAM-e has been shown to improve the flow of bile and replenish important antioxidants. A double-blind study concerning muscle health published in the Scandinavian Journal of Rheumatology showed that 800 mg daily of SAM-e supplementation for six weeks resulted in reduced pain, fatigue, and stiffness, and improved mood. SAM-e may also lower homocysteine levels, high levels of which have been proven to cause neurological and cardiovascular problems. Additionally, SAM-e is critical for transmethylation, the process that enables the body to repair cells and detoxify, and also affects the activation, synthesis and metabolism of various biological molecules.

The typical SAM-e dosage is 400-800 mg daily for promoting a healthy mood, liver and joints. It must be consumed as a tablet that is enteric-coated and is in the stabilized and standardized form. As SAM-e is 50% elemental, a product must provide 800 mg gross to equal 400 mg elemental, thereby making it beneficial. NSI SAM-e 200 mg (from 400 mg gross) offers 60 enteric-coated tablets. Additionally, NSI provides a SAM-e 400 mg (from 800 mg gross) supplement offering 30 enteric-coated tablets. NSI's SAM-e is pharmaceutical grade from Europe. Beware of some SAM-e products that are of inferior quality.

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